A simple blood test could
2020年9月23日We decided to see if it could be citrullinated and, if so, whether it was a target for the autoantibodies that attack the body in RA," said lead researcher Anja Schwenzer, from University of Oxford. "When it comes to rheumatoid arthritis, early diagnosis is key with research showing that there is often a narrow window of opportunity’ following the onset of symptoms for effective diagnosis and control of disease through treatment," said Stephen Simpson, Research Director for Arthritis Research UK. "This discovery therefore gives us an additional test that can be used to increase the accuracy of the CCP assay and that can predict RA, enabling us to monitor people and spot the disease early. That might also indicate whether it could be used in tests to indicate the disease," Schwenzer said.. When inflammation occurs in the body, some proteins are altered in a process called citrullination. Tests that spot antibodies to citrullinated proteins arealready used to diagnose the disease.
While tests for individual proteins usually have a relatively low diagnostic sensitivity, a more general test called CCP, that detects synthetic citrullinated peptides, identifies a lot more RA cases. This early detection is key because early treatment is more effective," Midwood said. These altered forms can prompt an immune response from the body, which can see it turning antibodies on itself - causing rheumatoid arthritis. The blood test looks for antibodies that recognise the protein tenascin-C and could reliably identify those who will contract rheumatoid arthritis (RA), researchers said.A simple blood test could predictrheumatoid arthritis risk up to 16 years before the onset of the painful and debilitating condition, Oxford scientists https://www.roomeye.cc/product/louver-window/aluminum-louver-window.html China wholesale Aluminium Casement Window say. "It also has a very low rate of false positives - it is 98 per cent accurate at ruling out RA," she said. "When we looked at results from more than 2,000 patients we found that testing for antibodies that target citrullinated tenascin-C (cTNC) could diagnose RA in around 50 per cent of cases, including some cases not identified by CCP," she said.
While tests for individual proteins usually have a relatively low diagnostic sensitivity, a more general test called CCP, that detects synthetic citrullinated peptides, identifies a lot more RA cases. This early detection is key because early treatment is more effective," Midwood said. These altered forms can prompt an immune response from the body, which can see it turning antibodies on itself - causing rheumatoid arthritis. The blood test looks for antibodies that recognise the protein tenascin-C and could reliably identify those who will contract rheumatoid arthritis (RA), researchers said.A simple blood test could predictrheumatoid arthritis risk up to 16 years before the onset of the painful and debilitating condition, Oxford scientists https://www.roomeye.cc/product/louver-window/aluminum-louver-window.html China wholesale Aluminium Casement Window say. "It also has a very low rate of false positives - it is 98 per cent accurate at ruling out RA," she said. "When we looked at results from more than 2,000 patients we found that testing for antibodies that target citrullinated tenascin-C (cTNC) could diagnose RA in around 50 per cent of cases, including some cases not identified by CCP," she said.
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